In The Substance, Elisabeth Sparkle (Demi Moore), a former Hollywood star in decline, is fired from her TV show on the very same day as her 50th birthday. After an accident, she discovers a mysterious serum that allows her to create a younger, perfect version of herself, named Sue (Margaret Qualley). The two personalities must alternate every seven days, but they soon develop a disturbing rivalry. As Sue gains fame and success, Elizabeth becomes increasingly obsessed and desperate, until a confrontation leads to grisly and destructive consequences.
In the seventeenth minute we watch Demi Moore naked as she showers, framed from above. This is a very brief sequence. At the twenty-second minute Demi is naked in front of the bathroom mirror, with her hands resting on the sink, looking at herself in the mirror. In a long sequence, the actress injects herself with a green serum and then has convulsions that cause her to fall to the floor and writhe. In the following scene, Margaret Qualley totally naked approaches the fogged bathroom mirror, wipes it with one hand, and admires her naked body. In this scene and throughout the film Margaret’s breasts are prosthetic. In the thirty-second minute Margaret Qualley is naked in the shower and massaging her body. We see Margaret’s beautiful ass again in the fortieth minute, when she drops her robe to the floor and is totally naked, framed from the back. The girl kneels before Demi Moore, lying naked and asleep on the bathroom floor, to inject herself with something. A moment later Margaret passes out on Demi, who instead wakes up in a daze. At the forty-fifth minute Margaret Qualley walks around the house in a T-shirt tied around her waist and a pair of pink panties that enhance her perfect ass. In the fifty-eighth minute, naked Demi Moore wakes up in a dark room. Next to her Margaret, naked, is lying on the floor asleep. Demi puts on a bathrobe and leaves the room.
In the seventeenth minute we watch Demi Moore naked as she showers, framed from above. This is a very brief sequence. At the twenty-second minute Demi is naked in front of the bathroom mirror, with her hands resting on the sink, looking at herself in the mirror. In a long sequence, the actress injects herself with a green serum and then has convulsions that cause her to fall to the floor and writhe. In the following scene, Margaret Qualley totally naked approaches the fogged bathroom mirror, wipes it with one hand, and admires her naked body. In this scene and throughout the film Margaret’s breasts are prosthetic. In the thirty-second minute Margaret Qualley is naked in the shower and massaging her body. We see Margaret’s beautiful ass again in the fortieth minute, when she drops her robe to the floor and is totally naked, framed from the back. The girl kneels before Demi Moore, lying naked and asleep on the bathroom floor, to inject herself with something. A moment later Margaret passes out on Demi, who instead wakes up in a daze. At the forty-fifth minute Margaret Qualley walks around the house in a T-shirt tied around her waist and a pair of pink panties that enhance her perfect ass. In the fifty-eighth minute, naked Demi Moore wakes up in a dark room. Next to her Margaret, naked, is lying on the floor asleep. Demi puts on a bathrobe and leaves the room.